Bacopa monnieri has been studied in animals for its purported effects on the functions of the central nervous system in its various forms such as, crude, standardized extract, and compounded formulation known as Brahmi Rasayan.
Constituents of Brahmi Rasayan
| Herb | Plant part used | Ratio (w/w) |
|---|---|---|
| Bacopa monnieri | Leaves | 10 |
| Eugenia caryophyllus (cloves) | Flower | 2 |
| Piper longum (long pepper) | Stalks | 1 |
| Elettaria cardamomum (cardamom) | Seed | 1 |
| Sucrose | 40 |
Oral administration of Bacopa monnieri in rat models for its support of learning acquisition, retention, and adaptive response to newly learned tasks.
Follow-up preclinical research examined the effects of Bacopa monnieri active components, bacosides A and B, on learning performance in animal models. Supplementation was associated with faster task acquisition and improved learning retention compared to controls.
In a separate aversion-learning model, animals receiving bacosides demonstrated improved adaptive learning responses when exposed to challenging stimuli. These observations reflected enhanced learning efficiency under experimental conditions.
Overall, the findings suggest that bacosides A and B support learning and memory processes in preclinical models, contributing to cognitive adaptability and overall brain health.
Summary of dosage regimen
| Group treatment | Dose of bacosides (mg/kg oral) |
|---|---|
| Bacoside A | |
| I Saline | 0.5 ml |
| II Bacoside | 2.5 |
| III Bacoside | 5.0 |
| IV Bacoside | 7.5 |
| V Bacoside | 5.0 (no LiCl incubation on day 1) |
| Bacosides A and B | |
| VI Saline | Saline 0.5 ml |
| VII Bacoside | 2.5 |
| VIII Bacoside | 5.0 |
| IX Bacoside | 7.5 |
| X Bacoside | 5.0 (no LiCl incubation on day 1) |
